Episode 132
Hematopoietic Stem Cells in Health, Aging and Malignancy: Focus on Metabolism (EHA2024)
In this episode on recent insights about metabolism of the hematopoietic stem cells (HSCs), Dr Krzysztof Szade from Jagellonian University in Krakow, Poland, discusses HSPc in health, aging and malignancy. This podcast recaps the findings that aim to elucidate the metabolic requirements of HSCs at different stages of aging.
Listen to Dr Szade summarize the data on how heme oxygenase-1 (HO-1) influences glycolytic metabolic stemness of HSCs, impacting on their self-renewal and differentiation. Follow his explanations of the hierarchical relationship between myeloid-biased and balanced HSCs and other observations shedding more light on the mechanisms of HSC aging. As the understanding of the metabolic requirements of HSCs during aging can point to new therapies for hematological disorders, tune in for this latest update.
Guest: Dr Krzysztof Szade
This episode is part of a series of lectures recorded at the EHA congress in Madrid in June 2024. This podcast containing accompanying slide content is available as a video on Spotify, YouTube, and EHA Campus. More lectures will be available in the future. Stay tuned!
For more information about a past or upcoming EHA Congress, visit https://ehaweb.org/congress/
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